Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid
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چکیده
منابع مشابه
Endemic (Balkan) nephropathy is aristolochic acid nephropathy.
Endemic nephropathy is a syndrome that comprises two entities: chronic interstitial nephropathy and urothelial cell cancers predominantly of the upper urinary tract. The etiological agent for the disease is aristolochic acid, a compound found in the plants of Aristolochia spp. The development of urothelial cancers is characterized by the formation of aristolactam DNA adducts leading to mutation...
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Division of Molecular Toxicology, German Cancer Research Center, Heidelberg, Germany Section of Molecular Carcinogenesis, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK Institute of Pathology, University of Ljubljana, Ljubljana, Slovenia Department of Biochemistry, Charles University, Prague, The Czech Republic Ecole Nationale Supérieure Agronomique de Toulouse, Laborat...
متن کاملAristolochic acid: the common culprit of Chinese herbs nephropathy and Balkan endemic nephropathy.
Balkan endemic nephropathy (BEN) is a devastating tubulointerstitial kidney disease affecting men and women living in rural areas of Bosnia–Herzegovina, Bulgaria, Croatia, Romania and Serbia [1]. The disease occurs exclusively in farming villages situated in valleys of the Danube River and its tributaries. Since its first description in 1956, the geographic distribution as well as other epidemi...
متن کاملAristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.
Balkan endemic nephropathy (BEN) is found in certain rural areas of the Balkans and affects at least 25,000 inhabitants. Of the many hypotheses on BEN, the Aristolochia hypothesis has recently gained ground substantiated by the investigations on aristolochic acid nephropathy (AAN). On both clinical and morphological grounds, AAN is very similar to BEN. That exposure to aristolochic acid (AA) of...
متن کاملAristolochic Acid- and Ochratoxin A-dna Adducts: Possible Markers of Balkan Endemic Nephropathy and Associated Urothelial Tumors?
The etiology of Balkan endemic nephropathy (BN) is still debated. The similar prevalence of the disease in immigrants and natives in endemic areas points to environmental etiological factors. Viral agents, selenium deficiency, cadmium, lead and long-term exposure to polycyclic aromatic hydrocarbons and amines have received little support. By contrast, BN is amazingly reminiscent of the findings...
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ژورنال
عنوان ژورنال: Seminars in Nephrology
سال: 2019
ISSN: 0270-9295
DOI: 10.1016/j.semnephrol.2019.02.007